Evaluation of urine N1,N12-Diacetylspermine as potential tumor marker for urinary bladder cancer.

BACKGROUND N1,N12-diacetylspermine, a diacetylpolyamine which was recently identified in urine, appeared to be a useful tumor marker for a number of cancers. No valid data on urine diacetylspermine concentration in patients with urinary bladder cancer exist. AIM Evaluation of urine N1,N12-diacetylspermine concentrations in individuals with urinary bladder cancer. METHODS Urine samples were used from 36 patients with urothelial tumors of the urinary bladder and from 30 patients with benign urological diseases. Urine was collected before cystoscopy. Enzyme-linked immunoabsorbent assays (ELISA) were performed for diacetylspermine from urine. RESULTS Urine diacetylspermine did not differentiate in individuals with urinary bladder cancer from controls (medians 171.5 vs 143.8, p = 0.64). Its efficacy for urinary bladder cancer detection was not shown. CONCLUSIONS Urine N1,N12-diacetylspermine is probably not a useful marker for urinary bladder cancer.